Olmesartan medoxomil is a new orally active angiotensin II type 1 receptor antagonist used as an anti-hypertensive agent. It is a prodrug and is rapidly de-esterified during absorption to form olmesartan, the active metabolite. Indapamide is an orally administered diuretic and anti-hypertensive drug. Its molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid soluble methyl-indoline moiety. It differs chemically from thiazide in a way that it does not possess the thiazide ring system and contains only one sulfonamide group. Currently most commonly prescribed medicines for hypertension are angiotensin receptor blockers and diuretics. Monotherapy with oral anti-hypertensive agents is not sufficient to achieve target blood pressure levels and henceforth, a combination tablet formulation is beneficial in terms of its convenience and patient compliance. The present drug combination has promising anti-hypertensive effect. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers 50 analytical methods including spectrophotometric methods like spectrophotometry, chromatographic method including HPLC, HPTLC were reported.
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